{"id":27,"date":"2026-06-24T15:08:58","date_gmt":"2026-06-24T06:08:58","guid":{"rendered":"https:\/\/home.hirosaki-u.ac.jp\/transport\/?page_id=27"},"modified":"2026-07-03T16:04:38","modified_gmt":"2026-07-03T07:04:38","slug":"publications","status":"publish","type":"page","link":"https:\/\/home.hirosaki-u.ac.jp\/transport\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

\u30fbYamada, K. A strategy for surviving: Looking through metastatic cancer and L-glucose. Viva Origino 53(1):<\/strong><\/em> 2 (2025), doi: 10.50968\/vivaorigino.53-1-2<\/a>.<\/span><\/p>\n

\u30fbOgawa, T., Sasaki, A., Ono, K., Ohshika, S., Ishibashi, Y., Yamada, K. Uptake of fluorescent D- and L-glucose analogues, 2-NBDG and 2-NBDLG, into human osteosarcoma U2OS cells in a phloretin-inhibitable manner. Human Cell 34<\/strong><\/em>: 634-643 (2021). doi: 10.1007\/s13577-020-00483-y<\/a>.<\/span><\/p>\n

\u30fbOno, K., Takigawa, S., Yamada, K. L-Glucose: Another Path to Cancer Cells. Cancers 12<\/strong><\/em>: 850 (2020). doi: 10.3390\/cancers12040850<\/a>.<\/span><\/p>\n

\u30fbShibasaki, K., Yamada, K., Miwa, H., Yanagawa, Y., Suzuki, M., Tominaga, M., Ishizaki, Y. Temperature elevation in epileptogenic foci exacerbates epileptic discharge through TRPV4 activation. Lab. Invest. 100<\/strong><\/em>: 274-284 (2020). doi: 10.1038\/s41374-019-0335-5<\/a>.<\/span><\/p>\n

\u30fbTakasugi, T., Hanaoka, K., Sasaki, A., Ikeno, T., Komatsu, T., Ueno, T., Yamada, K., Urano, Y. Development of a platform for activatable fluorescent substrates of glucose transporters (GLUTs). Bioorg. Med. Chem. 27<\/strong><\/em>: 2122-2126 (2019). doi: 10.1016\/j.bmc.2019.02.055<\/a>.<\/span><\/p>\n

\u30fbYamada, K. Aberrant Uptake of a Fluorescent L-Glucose Analogue (fLG) into Tumor Cells Expressing Malignant Phenotypes. Biol. Pharm. Bull. 41<\/strong><\/em>: 1508-1516 (2018). doi: 10.1248\/bpb.b18-00089<\/a>.<\/span><\/p>\n

\u30fbYamada, K., Sato, D., Nakamura, T., Amano, H., and Morimoto, Y. Unknown biological effects of L-glucose, ALA, and PUFA. J. Physiol. Sci. 67<\/strong><\/em>: 539-548 (2017). doi: 10.1007\/s12576-017-0544-x<\/a>.<\/span><\/p>\n

\u30fbNagatomo, K., Suga S. Saitoh, M., Kogawa, M., Kobayashi, K., Yamamoto, Y., and Yamada, K. Dopamine D1 receptor immunoreactivity on fine processes of GFAP-positive astrocytes in the substantia nigra pars reticulata of adult mouse. Front. Neuroanat. 11<\/strong><\/em>: (2017). doi: 10.3389\/fnana.2017.00003<\/a>.<\/span><\/p>\n

\u30fbShibasaki, K., Hosoi, N., Kaneko, R., Tominaga, M., and Yamada, K. Glycine release from astrocytes via functional reversal of GlyT1. J. Neurochem. 140<\/strong><\/em>: 395-403 (2017). doi: 10.1111\/jnc.13741<\/a>.<\/span><\/p>\n

\u30fbYamada, K. “Vascular potassium channels in NVC” pp 63-73, In, New Horizons in Neurovascular Coupling, A Bridge Between Brain Circulation and Neuronal Plasticity. (Progress in Brain Research 225) 279 pages, Ed. by. Masamoto, K., Hirase, H., Yamada, K. Elsevier, Amsterdam (2016). doi: 10.1016\/bs.pbr.2016.01.001<\/a>.<\/span><\/p>\n

\u30fbYamada, K., Takahashi, S., Karube, F., Fujiyama, F., Kobayashi, K., Nishi, A., Momiyama, T. Neuronal circuits and physiological roles of the basal ganglia in terms of transmitters, receptors and related disorders. J. Physiol. Sci. 66<\/strong><\/em>: 435-446 (2016). doi: 10.1007\/s12576-016-0445-4<\/a>.<\/span><\/p>\n

\u30fbOtsuka, Y., Sasaki, A., Teshima, T., Yamada, K., Yamamoto, T. Syntheses of D-Glucose Derivatives Emitting Blue Fluorescence through Pd-Catalyzed C-N Coupling. Org. Lett. 18<\/strong><\/em>: 1338-1341 (2016). doi: 10.1021\/acs.orglett.6b00280<\/a>.<\/span><\/p>\n

\u30fbYokoyama, H., Sasaki, A., Yoshizawa, T., Kijima, H., Hakamada, K., Yamada, K. Imaging hamster model of bile duct cancer in vivo using fluorescent L-glucose derivatives. Human Cell 29<\/strong><\/em>: 111-121 (2016). doi: 10.1007\/s13577-015-0131-5<\/a>.<\/span><\/p>\n

\u30fbSasaki, A., Nagatomo, K., Ono, K., Yamamoto, T., Otsuka, Y., Teshima, T., Yamada, K. Uptake of a fluorescent L-glucose derivative 2-NBDLG into three-dimensionally accumulating insulinoma cells in a phloretin-sensitive manner. Human Cell 29<\/strong><\/em>: 37-45 (2016). doi: 10.1007\/s13577-015-0125-3<\/a>.<\/span><\/p>\n

\u30fbSasaki, A., Nagatomo, K., Ono, K., Yamamoto, T., Otsuka, Y., Teshima, T., Yamada, K. Erratum to: Uptake of a fluorescent L-glucose derivative 2-NBDLG into three-dimensionally accumulating insulinoma cells in a phloretin-sensitive manner. Human Cell 29<\/strong><\/em>: 138-139 (2016). doi: 10.1007\/s13577-016-0135-9<\/a>.<\/span><\/p>\n

\u30fbKurogi, M., Kawai, Y., Nagatomo, K., Tateyama, M., Kubo, Y., Saitoh, O. Auto-oxidation products of epigallocatechin gallate activate TRPA1 and TRPV1 in sensory neurons. Chem. Senses 40<\/strong><\/em>: 27-46 (2015). doi: 10.1093\/chemse\/bju057<\/a>.<\/span><\/p>\n

\u30fbYamamoto, Y., Miyamoto, M., Tatsuda, D., Kubo, M., Nakagama, H., Nakamura, Y., Satoh, H., Matsuda, K., Watanabe, T., Ohta, T. A rare polymorphic variant of NBS1 reduces DNA repair activity and elevates chromosomal instability. Cancer Res. 74<\/strong><\/em>: 3707-3715 (2014). doi: 10.1158\/0008-5472.CAN-13-3037<\/a>.<\/span><\/p>\n

\u30fbMiyazaki, H., Oyama, F., Inoue, R., Aosaki, T., Abe, T., Kiyonari, H., Kino, Y., Kurosawa, M., Shimizu, J., Ogiwara, I., Yamakawa, K., Koshimizu, Y., Fujiyama, F., Kaneko, T., Shimizu, H., Nagatomo, K., Yamada, K., Shimogori, T., Hattori, N., Miura, M., Nukina, N. Singular localization of sodium channel \u03b24 subunit in unmyelinated fibres and its role in the striatum. Nat. Commun. 5<\/strong><\/em>: 5525 (2014). doi: 10.1038\/ncomms6525<\/a>.<\/span><\/p>\n

\u30fbYamamoto, T., Tanaka, S., Suga, S., Watanabe, S., Nagatomo, K., Sasaki, A., Nishiuchi, Y., Teshima, T. and Yamada, K. Syntheses of 2-NBDG analogues for monitoring stereoselective uptake of D-glucose. Bioorg. Med. Chem. Lett. 21<\/strong><\/em>: 4088-4096 (2011). doi: 10.1016\/j.bmcl.2011.04.148<\/a>.<\/span><\/p>\n

\u30fbNagatomo, K., Ishii, H., Yamamoto, T., Nakajo, K. and Kubo, Y. The Met268Pro mutation of mouse TRPA1 changes the effect of caffeine from activation to suppression. Biophys. J. 99<\/strong><\/em>: 3609-3618 (2010). doi: 10.1016\/j.bpj.2010.10.014<\/a>.<\/span><\/p>\n

\u30fbKurogi, M., Nagatomo, K., Kubo, Y. and Saitoh, O. Effects of spinophilin on the function of RGS8 regulating signals from M2 and M3-mAChRs. Neuroreport 20<\/strong><\/em>: 1134-1139 (2009). doi: 10.1097\/WNR.0b013e32832fd93e<\/a>.<\/span><\/p>\n

\u30fbYamamoto, T., Nishiuchi, Y., Teshima, T., Matsuoka, H., and Yamada, K. Synthesis of 2-NBDLG, a fluorescent derivative of L-glucosamine; the antipode of D-glucose tracer 2-NBDG. Tetrahedron Lett. 49<\/strong><\/em>: 6876-6878 (2008). doi: 10.1016\/j.tetlet.2008.09.089<\/a>.<\/span><\/p>\n

\u30fbSakai, H., Tanaka, Y., Tanaka M., Ban, N., Yamada, K., Matsumura, Y., Sasaki, M., Kita, T., Inagaki, N. ABCA2 deficiency results in abnormal sphingolipid metabolism in mouse brain. J. Biol. Chem. 282<\/strong><\/em>: 19692-19699 (2007). doi: 10.1074\/jbcM611056200<\/a>.<\/span><\/p>\n

\u30fbYamada, K., Saito, M., Matsuoka, H., Inagaki, N. A real-time method of imaging glucose uptake in single, living mammalian cells. Nature Protocols 2<\/strong><\/em>: 753-762 (2007). doi: 10.1038\/nprot.2007.76<\/a>.<\/span><\/p>\n

\u30fbMiyake, A., Yamada, K., Kosaka, T., Miki, T., Seino, S., Inagaki, N. Disruption of Kir6.2-containing ATP-sensitive potassium channels impairs maintenance of hypoxic gasping in mice. Eur J Neurosci. 25<\/strong><\/em>: 2349-236 (2007). doi: 10.1111\/j.1460-9568.2007.05499.x<\/a>.<\/span><\/p>\n

\u30fbSaito, T., Yamada, K., Wang, Y., Tanaka, Y., Ohtomo, K., Ishikawa, K., Inagaki, N. Expression of ABCA2 protein in both non-myelin-forming and myelin-forming Schwann cells in the rodent peripheral nerve. Neurosci. Lett. 414<\/strong><\/em>: 35-40 (2007). doi: 10.1016\/j.neulet.2006.12.028<\/a>.<\/span><\/p>\n

\u30fbSato, S., Yamada, K., and Inagaki, N. Systems for simultaneously monitoring heart and breathing rate in mice using a piezoelectric transducer. Med. Bioeng. Comput. 44<\/strong><\/em>: 353-362 (2006). doi: 10.1007\/s11517-006-0047-z<\/a>.<\/span><\/p>\n

\u30fbYamada, K., and Inagaki, N. Neuroprotection by KATP channels. J. Mol. Cell. Cardiol. 38<\/strong><\/em>: 945-949 (2005). doi: 10.1016\/j.yjmcc.2004.11.020<\/a>.<\/span><\/p>\n

\u30fbWang, Y., Yamada, K., Tanaka, Y., Ishikawa, K., and Inagaki, N. Expression of ABCA2 protein in human vestibular schwannoma and peripheral nerve. J. Neurol. Sci. 232<\/strong><\/em>: 59-63 (2005). doi: 10.1016\/j.jns.2005.01.016<\/a>.<\/span><\/p>\n

\u30fbYuan, H., Yamada, K., Inagaki, N. Multiminute oscillations in mouse substantia nigra pars reticulata neurons in vitro. Neurosci. Lett. 355<\/strong><\/em>: 136-140 (2004). doi: 10.1016\/j.neulet.2003.10.058<\/a>.<\/span><\/p>\n

\u30fbTanaka, U., Yamada, K., Zhou C.-J., Ban, N., Shioda, S., and Inagaki, N. Temporal and spatial profiles of ABCA2-expressing oligodendrocytes in the developing rat brain. J. Comp. Neurol. 455<\/strong><\/em>: 353-367 (2003). doi: 10.1002\/cne.10493<\/a>.<\/span><\/p>\n

\u30fbYamada, K., and Inagaki, N. ATP-sensitive potassium channels in the Brain: a sensor of hypoxic conditions. News Physiol. Sci. 17<\/strong><\/em>: 127-130 (2002). doi: 10.1152\/nips.01384.2001<\/a>.<\/span><\/p>\n

\u30fbOgura, T., Furukawa, T., Toyozaki, T., Yamada, K., Y.-U, Zheng, Katayama, Y., Nakaya, H., and Inagaki, N. ClC-3B, a novel ClC-3 splicing variant that interacts with EBP50 and facilitates expression of CFTR-regulated ORCC. FASEB J. 16<\/strong><\/em>: 863-865 (2002). doi: 10.1096\/fj.01-0845fje<\/a>.<\/span><\/p>\n

\u30fbYamada, K., and Inagaki, N. Metabolic control of the seizure gate: a role for neuronal K-ATP channels. Trends Pharmacol. Sci. 22<\/strong><\/em>: 601-602 (2001).<\/span><\/p>\n

\u30fbYamada, K., Ji, J.-J., Yuan, H., Miki, T., Sato, S., Horimoto, N., Shimizu, T., Seino, S., and Inagaki, N. Protective role of ATP-sensitive potassium channels in hypoxia-induced generalized seizure. Science 292<\/strong><\/em>: 1543-1546 (2001). doi: 10.1126\/science.1059829<\/a>.<\/span><\/p>\n

\u30fbYamada, K., Yamamoto, N., and Toyama, K. Development of NMDA and non-NMDA receptor-mediated excitatory synaptic transmission in geniculocortical and corticocortical connections studied by organotypic coculture preparations. Eur. J. Neurosci. 12<\/strong><\/em>: 3854-3862 (2000). doi: 10.1046\/j.1460-9568.2000.00268x<\/a>.<\/span><\/p>\n

\u30fbFujita, H., Matsuura, T., Yamada, K., Inagaki, N., and Kanno, I. A sealed cranial window system for simultaneous recording of blood flow, electrical and optical signals in the rat barrel cortex. J. Neurosci. Methods. 99<\/strong><\/em>: 71-78 (2000). doi: 10.1016\/S0165-0270(00)00215-6<\/a>.<\/span><\/p>\n

\u30fbYamada, K., Nakata, M., Horimoto, N., Saito, M., Matsuoka, H., and Inagaki, N. Measurement of glucose uptake and intracellular calcium concentration in single, living pancreatic \u03b2-cells. J. Biol. Chem. 275<\/strong><\/em>: 22278-22283 (2000). doi: 10.1074\/jbcM908048199<\/a>.<\/span><\/p>\n

\u30fbYamada, K., Yamamoto, N., and Toyama, K. Development of membrane properties of rat neocortical neurons studied in organotypic cocultures. Neurosci. Lett. 275<\/strong><\/em>: 65-68 (1999). doi: 10.1016\/S0304-3940(99)00745-4<\/a>.<\/span><\/p>\n

\u30fbMatsuura, T., Fujita, H., Seki, C., Kashikura, K., Yamada, K., and Kanno I. CBF Change evoked by somatosensory activation measured by laser-Doppler flowmetry: Independent evaluation of RBC velocity and RBC concentration. Jpn. J. Physiol. 49<\/strong><\/em>: 289-296 (1999). doi: 10.2170\/jjphysiol.49.289<\/a>.<\/span><\/p>\n

\u30fbMalonek, D., Dirnagl, U., Lindauer, U., Yamada, K., Kanno, I., and Grinvald, A. Vascular imprints of neuronal acitvity: Relationships between the dynamics of cortical blood flow, oxygenation, and volume changes following sensory stimulation. Proc. Natl. Acad. Sci. USA 94<\/strong><\/em>: 14826-14831 (1997). doi: 10.1073\/pnas.94.26.14826<\/a>.<\/span><\/p>\n

\u30fbYamamoto, N., Yamada, K., Kurotani, T., and Toyama, K. Laminar Specificity of Extrinsic Cortical Connections Studied in Coculture Preparations. Neuron 9<\/strong><\/em>: 217-228 (1992). doi: 10.1016\/0896-6273(92)90161-6<\/a>.<\/span><\/p>\n

\u30fbToyama, K., Komatsu, Y., Yamamoto, N., Kurotani, T., and Yamada, K. In vitro approach to visual cortical development and plasticity. Neurosci. Res. 12<\/strong><\/em>: 57-71 (1991) doi: 10.1016\/0168-0102(91)90100-D<\/a>.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

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