{"id":450,"date":"2023-10-17T10:34:38","date_gmt":"2023-10-17T01:34:38","guid":{"rendered":"https:\/\/home.hirosaki-u.ac.jp\/moritalab\/?p=450"},"modified":"2023-10-17T13:54:46","modified_gmt":"2023-10-17T04:54:46","slug":"%e5%8f%97%e8%a8%97%e7%a0%94%e7%a9%b6%e3%83%bb%e5%85%b1%e5%90%8c%e7%a0%94%e7%a9%b6%e5%8b%9f%e9%9b%86","status":"publish","type":"post","link":"https:\/\/home.hirosaki-u.ac.jp\/moritalab\/450\/","title":{"rendered":"\u53d7\u8a17\u7814\u7a76\u30fb\u5171\u540c\u7814\u7a76\u52df\u96c6"},"content":{"rendered":"<p>\u5f53\u7814\u7a76\u5ba4\u3067\u306f\u3001\u30d0\u30a4\u30aa\u30bb\u30fc\u30d5\u30c6\u30a3\u30fc\u30ec\u30d9\u30eb\uff08BSL\uff093\u304a\u3088\u3073BSL2\u5b9f\u9a13\u5ba4\u304c\u7a3c\u50cd\u4e2d\u3067\u3042\u308a\u3001\u3053\u308c\u3089\u306e\u65bd\u8a2d\u3092\u6d3b\u7528\u3057\u305f\u5171\u540c\u7814\u7a76\u3084\u53d7\u8a17\u7814\u7a76\u306e\u6a5f\u4f1a\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u5f53\u7814\u7a76\u5ba4\u3067\u72ec\u81ea\u306b\u958b\u767a\u3057\u305f\u6280\u8853\u3092\u6d3b\u7528\u3057\u305f\u5171\u540c\u7814\u7a76\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306b\u3064\u3044\u3066\u3082\u7a4d\u6975\u7684\u306b\u52df\u96c6\u3057\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n<p><span style=\"font-size: 24pt;color: #0000ff\">\u6297\u30a6\u30a4\u30eb\u30b9\u5897\u6b96\u6d3b\u6027\u306e\u6e2c\u5b9a<\/span><\/p>\n<p>\u5f53\u7814\u7a76\u5ba4\u3067\u306f\u3001in vitro\u57f9\u990a\u7d30\u80de\u3092\u7528\u3044\u3066\u3001\u4ee5\u4e0b\u306b\u793a\u3059\u3055\u307e\u3056\u307e\u306a\u75c5\u539f\u4f53\u306e\u611f\u67d3\u5b9f\u9a13\u3092\u5b9f\u65bd\u3067\u304d\u308b\u4f53\u5236\u3092\u6574\u3048\u3066\u304a\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u975e\u81ea\u7acb\u5897\u6b96\u578b\u7d44\u63db\u3048\u30a6\u30a4\u30eb\u30b9\u3084\u3001\u30ec\u30d7\u30ea\u30b3\u30f3\u30b7\u30b9\u30c6\u30e0\u3082\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u3092\u7528\u3044\u3066\u3001\u5316\u5408\u7269\u3084\u5929\u7136\u62bd\u51fa\u7269\u306b\u542b\u307e\u308c\u308b\u7269\u8cea\u304c\u75c5\u539f\u4f53\u306e\u5897\u6b96\u3092\u6291\u5236\u3059\u308b\u52b9\u679c\u3092\u691c\u8a3c\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002\u305d\u306e\u4ed6\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u75c5\u539f\u4f53\u3092\u65b0\u305f\u306b\u5165\u624b\u3057\u89e3\u6790\u3059\u308b\u3053\u3068\u3082\u53ef\u80fd\u3067\u3059\u3002<\/p>\n<p><span style=\"color: #ff0000\">BSL3\u3067\u6271\u3046\u30a6\u30a4\u30eb\u30b9(\u81ea\u7acb\u5897\u6b96\u578b\u751f\u30a6\u30a4\u30eb\u30b9)<\/span><\/p>\n<ul>\n<li>\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9<em>Severe acute\u00a0respiratory syndrome\u00a0coronavirus 2<\/em> (SARS-CoV-2)<\/li>\n<\/ul>\n<p><span style=\"color: #ff0000\">BSL2\u3067\u6271\u3046\u30a6\u30a4\u30eb\u30b9<\/span><span style=\"color: #ff0000\">(\u81ea\u7acb\u5897\u6b96\u578b\u751f\u30a6\u30a4\u30eb\u30b9)<\/span><\/p>\n<ul>\n<li>\u30d2\u30c8\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9 OC43\u682a <i>Human Coronavirus OC43\u00a0 strain<\/i><\/li>\n<li>\u30d2\u30c8\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9 229E\u682a <i>Human Coronavirus 229E\u00a0 strain<\/i><\/li>\n<li>A\u578b\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30a6\u30a4\u30eb\u30b9PR8\u682a <em>Influenza virus H1N1 PR8 strain<\/em><\/li>\n<li>\u30c7\u30f3\u30b0\u30a6\u30a4\u30eb\u30b9 2\u578b NGC\u682a <em>Dengue Virus NGC strain<\/em><\/li>\n<li>\u65e5\u672c\u8133\u708e\u30a6\u30a4\u30eb\u30b9 AT31\u682a <em>Japanese Encephalitis Virus AT31 strain<\/em><\/li>\n<li>\u30a8\u30f3\u30c6\u30ed\u30a6\u30a4\u30eb\u30b9 71 C7\/Osaka \u682a <em>Enterovirus 71 C7\/Osaka\u00a0<\/em><\/li>\n<li>\u30b3\u30af\u30b5\u30c3\u30ad\u30fc\u30a6\u30a4\u30eb\u30b9B3 Nancy\u682a <em>Coxsackievirus B3 Nancy strain<\/em><\/li>\n<li>\u30d2\u30c8\u30a2\u30c7\u30ce\u30a6\u30a4\u30eb\u30b95\u578b <em>Human Adenovirus type 5<\/em><\/li>\n<li>\u9ebb\u75b9\u30a6\u30a4\u30eb\u30b9\u3000<em>Measles Virus Edmonston strain<\/em><\/li>\n<li>\u30d2\u30c8\u30d1\u30eb\u30dc\u30a6\u30a4\u30eb\u30b9B19 <em>Human Parvovirus B19<\/em><\/li>\n<li>\u5358\u7d14\u30d8\u30eb\u30da\u30b9\u30a6\u30a4\u30eb\u30b9I\u578b <em>Herpes Simplex Virus type I<\/em><\/li>\n<\/ul>\n<p><span style=\"color: #ff0000\">\u975e\u81ea\u7acb\u5897\u6b96\u578b\u7d44\u63db\u3048\u30a6\u30a4\u30eb\u30b9<\/span><\/p>\n<ul>\n<li>\u30d2\u30c8\u514d\u75ab\u4e0d\u5168\u30a6\u30a4\u30eb\u30b9 NL43\u682a <em>Human Immunodeficiency Virus type I<\/em><\/li>\n<\/ul>\n<p><span style=\"color: #ff0000\">\u9ad8\u611f\u5ea6\u30ec\u30dd\u30fc\u30bf\u30fc\u30ec\u30d7\u30ea\u30b3\u30f3\u30b7\u30b9\u30c6\u30e0\uff08\u7d30\u80de\u5185\u30a6\u30a4\u30eb\u30b9\u30b2\u30ce\u30e0\u8907\u88fd\u3092\u8a55\u4fa1\u3059\u308b\u30b7\u30b9\u30c6\u30e0\uff09<\/span><\/p>\n<ul>\n<li>\u65e5\u672c\u8133\u708e\u30a6\u30a4\u30eb\u30b9<\/li>\n<li>\u30c7\u30f3\u30b0\u30a6\u30a4\u30eb\u30b9 2\u578b<\/li>\n<li>\u30a8\u30f3\u30c6\u30ed\u30a6\u30a4\u30eb\u30b9 71<\/li>\n<li>\u30b3\u30af\u30b5\u30c3\u30ad\u30fc\u30a6\u30a4\u30eb\u30b9B3<\/li>\n<li>\u30b7\u30f3\u30c9\u30d3\u30b9\u30a6\u30a4\u30eb\u30b9<\/li>\n<\/ul>\n<p><span style=\"font-size: 24pt;color: #0000ff\">\u8d85\u9ad8\u611f\u5ea6\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u6d3b\u6027\u6e2c\u5b9a\u6cd5\u3092\u7528\u3044\u305f\u89e3\u6790<\/span><\/p>\n<p>\u86cb\u767d\u8cea\u306e\u90e8\u5206\u5206\u89e3\u306f\u3001\u86cb\u767d\u8cea\u5207\u65ad\u9175\u7d20\uff08\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\uff09\u306b\u3088\u3063\u3066\u5b9f\u884c\u3055\u308c\u3001\u7d30\u80de\u5185\u306e\u3055\u307e\u3056\u307e\u306a\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3084\u7d30\u80de\u306e\u6d3b\u6027\u5316\u306b\u304a\u3044\u3066\u975e\u5e38\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u3053\u306e\u6d3b\u6027\u306f\u591a\u304f\u306e\u30a6\u30a4\u30eb\u30b9\u306e\u5897\u6b96\u306b\u4e0d\u53ef\u6b20\u3067\u3042\u308a\u3001\u30d2\u30c8\u514d\u75ab\u4e0d\u5168\u30a6\u30a4\u30eb\u30b9\u3084\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u306a\u3069\u3078\u306e\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u306e\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u79c1\u305f\u3061\u306f\u3053\u308c\u307e\u3067\u306b\u3001\u7d30\u80de\u5185\u306e\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u6d3b\u6027\u3092\u9ad8\u611f\u5ea6\u304b\u3064\u7c21\u4fbf\u306b\u5b9a\u91cf\u3059\u308b\u30bb\u30f3\u30b5\u30fc\u3092\u958b\u767a\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u30bb\u30f3\u30b5\u30fc\u306f\u5f93\u6765\u306e\u86cd\u5149\u86cb\u767d\u8cea\u30d9\u30fc\u30b9\u306e\u30bb\u30f3\u30b5\u30fc\u3068\u6bd4\u8f03\u3057\u3066\u3001\u7d04500\u500d\u306e\u611f\u5ea6\u3092\u793a\u3059\u305f\u3081\u3001\u3053\u308c\u307e\u3067\u691c\u51fa\u3067\u304d\u306a\u304b\u3063\u305f\u591a\u304f\u306e\u6d3b\u6027\u3092\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u9ad8\u611f\u5ea6\u3067\u3042\u308b\u305f\u3081\u3001\u30cf\u30a4\u30b9\u30eb\u30fc\u30d7\u30c3\u30c8\u89e3\u6790\u306b\u3082\u9069\u3057\u3066\u3044\u307e\u3059\u3002\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u30bb\u30f3\u30b5\u30fc\u306e\u8a2d\u8a08\u304b\u3089\u30a2\u30c3\u30bb\u30a4\u307e\u3067\u3001\u5e45\u5e83\u3044\u30cb\u30fc\u30ba\u306b\u5bfe\u5fdc\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n<p>Arakawa, M., Yoshida, A., Okamura, S., Ebina, H., Morita, E. A highly sensitive NanoLuc-based protease biosensor for detecting apoptosis and SARS-CoV-2 infection. <em><strong>Sci Rep.<\/strong> <\/em>2023 13(1)1753. Doi: 10.1038\/s41598-023-28984-4<\/p>\n<p><span style=\"font-size: 24pt;color: #0000ff\">\u8d85\u9ad8\u611f\u5ea6\u30bf\u30f3\u30d1\u30af\u8cea\u76f8\u4e92\u4f5c\u7528\u5b9a\u91cf\u89e3\u6790<\/span><\/p>\n<p>\u30d7\u30eb\u30c0\u30a6\u30f3\u30a2\u30c3\u30bb\u30a4\u306b\u3088\u308b\u86cb\u767d\u8cea\u306e\u76f8\u4e92\u4f5c\u7528\u89e3\u6790\u306f\u3001\u30a6\u30a8\u30b9\u30bf\u30f3\u30d6\u30ed\u30c3\u30c8\u306a\u3069\u306e\u691c\u51fa\u624b\u6cd5\u3092\u5fc5\u8981\u3068\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u30a6\u30a8\u30b9\u30bf\u30f3\u30d6\u30ed\u30c3\u30c8\u6cd5\u306f\u691c\u51fa\u611f\u5ea6\u3068\u5b9a\u91cf\u6027\u306b\u5236\u7d04\u304c\u3042\u308b\u3053\u3068\u304c\u4e00\u822c\u7684\u3067\u3059\u3002\u3053\u306e\u554f\u984c\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u306b\u3001\u8d85\u9ad8\u611f\u5ea6\u3067\u5171\u6c88\u964d\u3057\u305f\u86cb\u767d\u8cea\u3092\u5b9a\u91cf\u7684\u306b\u691c\u51fa\u3067\u304d\u308b\u624b\u6cd5\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u5c0f\u898f\u6a21\u306a\u30a2\u30c3\u30bb\u30a4\u306b\u3088\u308b\u30cf\u30a4\u30b9\u30eb\u30fc\u30d7\u30c3\u30c8\u89e3\u6790\u306b\u3082\u9069\u7528\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u7cbe\u88fd\u3057\u305f\u86cb\u767d\u8cea\u3092\u7528\u3044\u305fin vitro\u89e3\u6790\u3060\u3051\u3067\u306a\u304f\u3001\u7d30\u80de\u5185\u3067\u306ein vivo\u74b0\u5883\u3067\u306e\u8907\u96d1\u306a\u86cb\u767d\u8cea\u8907\u5408\u4f53\u306e\u89e3\u6790\u3084\u5fae\u7d30\u306a\u86cb\u767d\u8cea\u9593\u306e\u7d50\u5408\u529b\u306e\u9055\u3044\u3092\u5b9a\u91cf\u7684\u306b\u8abf\u3079\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u6211\u3005\u306f\u591a\u7a2e\u591a\u69d8\u306a\u30d9\u30af\u30bf\u30fc\u3084\u30ce\u30a6\u30cf\u30a6\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002\u8208\u5473\u3092\u304a\u6301\u3061\u306e\u65b9\u306f\u305c\u3072\u304a\u6c17\u8efd\u306b\u304a\u554f\u3044\u5408\u308f\u305b\u304f\u3060\u3055\u3044\u3002<\/p>\n<p>Arakawa, M., Morita, E. Protein Pull-down Assay Using HiBiT-tag-dependent Luciferase Activity Measurement. <em><strong>Bioprotocol.<\/strong><\/em> 2023 13(6) e4640. DOI: 10.21769\/BioProtoc.4640<\/p>\n<p><span style=\"font-size: 18pt;color: #ff0000\">\u9023\u7d61\u5148<\/span><\/p>\n<p>\u5f18\u524d\u5927\u5b66 \u8fb2\u5b66\u751f\u547d\u79d1\u5b66\u90e8 \u5206\u5b50\u751f\u547d\u79d1\u5b66\u79d1 \u7d30\u80de\u5206\u5b50\u751f\u7269\u5b66\u5206\u91ce<\/p>\n<p>\u3012036-8561\u9752\u68ee\u770c\u5f18\u524d\u5e02\u6587\u4eac\u753a3\u3000\u96fb\u8a71\u756a\u53f70172-39-3586<\/p>\n<p>\u68ee\u7530\u82f1\u55e3\u3000<a href=\"mailto:moritae@hirosaki-u.ac.jp\">moritae@hirosaki-u.ac.jp<\/a><\/p>\n<p>\u7af9\u6d6a\u611b\u00a0 \u00a0<a href=\"mailto:ai0407@hirosaki-u.ac.jp\">ai0407@hirosaki-u.ac.jp<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5f53\u7814\u7a76\u5ba4\u3067\u306f\u3001\u30d0\u30a4\u30aa\u30bb\u30fc\u30d5\u30c6\u30a3\u30fc\u30ec\u30d9\u30eb\uff08BSL\uff093\u304a\u3088\u3073BSL2\u5b9f\u9a13\u5ba4\u304c\u7a3c\u50cd\u4e2d\u3067\u3042\u308a\u3001\u3053\u308c\u3089\u306e\u65bd\u8a2d\u3092\u6d3b\u7528\u3057\u305f\u5171\u540c\u7814\u7a76\u3084\u53d7\u8a17\u7814\u7a76\u306e\u6a5f\u4f1a\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u5f53\u7814\u7a76\u5ba4\u3067\u72ec\u81ea\u306b\u958b\u767a\u3057\u305f\u6280\u8853\u3092\u6d3b\u7528\u3057\u305f\u5171\u540c\u7814\u7a76\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306b\u3064 [&hellip;]<\/p>\n","protected":false},"author":196,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-450","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/home.hirosaki-u.ac.jp\/moritalab\/wp-json\/wp\/v2\/posts\/450","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/home.hirosaki-u.ac.jp\/moritalab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/home.hirosaki-u.ac.jp\/moritalab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/home.hirosaki-u.ac.jp\/moritalab\/wp-json\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/home.hirosaki-u.ac.jp\/moritalab\/wp-json\/wp\/v2\/comments?post=450"}],"version-history":[{"count":26,"href":"https:\/\/home.hirosaki-u.ac.jp\/moritalab\/wp-json\/wp\/v2\/posts\/450\/revisions"}],"predecessor-version":[{"id":478,"href":"https:\/\/home.hirosaki-u.ac.jp\/moritalab\/wp-json\/wp\/v2\/posts\/450\/revisions\/478"}],"wp:attachment":[{"href":"https:\/\/home.hirosaki-u.ac.jp\/moritalab\/wp-json\/wp\/v2\/media?parent=450"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/home.hirosaki-u.ac.jp\/moritalab\/wp-json\/wp\/v2\/categories?post=450"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/home.hirosaki-u.ac.jp\/moritalab\/wp-json\/wp\/v2\/tags?post=450"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}