{"id":20,"date":"2023-08-03T19:03:38","date_gmt":"2023-08-03T10:03:38","guid":{"rendered":"https:\/\/home.hirosaki-u.ac.jp\/mizutalab\/?page_id=20"},"modified":"2023-08-14T13:46:12","modified_gmt":"2023-08-14T04:46:12","slug":"20-2","status":"publish","type":"page","link":"https:\/\/home.hirosaki-u.ac.jp\/mizutalab\/20-2\/","title":{"rendered":"\u7814\u7a76\u7d39\u4ecb"},"content":{"rendered":"<h2 style=\"border-bottom: 3px solid #013365;color: #013365\">\u7814\u7a76\u30c6\u30fc\u30de<\/h2>\n<p>\u79c1\u305f\u3061\u306e\u7814\u7a76\u5ba4\u3067\u306f\u3001\u30b2\u30ce\u30e0\u3084\u30a2\u30df\u30ce\u9178\u914d\u5217\u306e\u89e3\u6790\u306b\u65b0\u305f\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u63a1\u7528\u3057\u3066\u3044\u307e\u3059\u3002\u30b2\u30ce\u30e0\u3084\u30a2\u30df\u30ce\u9178\u305d\u308c\u305e\u308c\u306b\u7269\u7406\u7684\u7279\u6027\u306a\u3069\u3092\u8003\u616e\u3057\u305f\u30d9\u30af\u30c8\u30eb\u3092\u5272\u308a\u5f53\u3066\u3001\u30b0\u30e9\u30d5\u8868\u793a\u3059\u308b\u3053\u3068\u3067\u8a08\u7b97\u91cf\u3092\u524a\u6e1b\u3057\u3001\u8996\u899a\u7684\u306a\u7406\u89e3\u3092\u9ad8\u3081\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u81a8\u5927\u306a\u60c5\u5831\u3092\u52b9\u7387\u7684\u306b\u89e3\u6790\u3067\u304d\u307e\u3059\u3002\u30b0\u30e9\u30d5\u8868\u793a\u753b\u50cf\u306e\u89e3\u6790\u306b\u306f<\/p>\n<ul>\n<li><a href=\"https:\/\/www.nttcoms.com\/service\/research\/dataanalysis\/principal-component-analysis\/#:~:text=%E4%B8%BB%E6%88%90%E5%88%86%E5%88%86%E6%9E%90%E3%81%A8%E3%81%AF%E3%80%81%E5%A4%9A%E3%81%8F%E3%81%AE%E5%A4%89%E6%95%B0%E3%82%92%E6%8C%81%E3%81%A4,%E6%8C%99%E3%81%92%E3%81%A6%E3%81%BF%E3%81%BE%E3%81%97%E3%82%87%E3%81%86%E3%80%82\">\u4e3b\u6210\u5206\u5206\u6790<\/a><\/li>\n<li><a href=\"https:\/\/www.nri.com\/jp\/knowledge\/glossary\/lst\/ka\/machine_learning#:~:text=%E6%A9%9F%E6%A2%B0%E5%AD%A6%E7%BF%92%E3%81%A8%E3%81%AF,%E3%82%8B%E3%82%88%E3%81%86%E3%81%AB%E3%81%AA%E3%81%A3%E3%81%9F%E3%80%82\">\u6a5f\u68b0\u5b66\u7fd2<\/a><\/li>\n<\/ul>\n<p>\u3092\u4e3b\u306b\u7528\u3044\u3066\u3001<a href=\"#classification1\"><strong style=\"color: #013365\">\u751f\u7269\u7a2e\u5206\u985e<\/strong><\/a>\u3084<a href=\"#classification2\"><strong style=\"color: #013365\">\u30bf\u30f3\u30d1\u30af\u8cea\u30d5\u30a1\u30df\u30ea\u30fc\u5206\u985e<\/strong><\/a>\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u5177\u4f53\u7684\u306a\u753b\u50cf\u306e\u7cbe\u88fd\u65b9\u6cd5\u306b\u3064\u3044\u3066\u306f\u3001\u4e0b\u56f3\u3092\u7528\u3044\u3066\u8aac\u660e\u3057\u307e\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-121 aligncenter\" src=\"http:\/\/home.hirosaki-u.ac.jp\/mizutalab\/wp-content\/uploads\/sites\/95\/Screenshot-from-2023-08-14-10-16-01-300x186.png\" alt=\"\" width=\"377\" height=\"234\" srcset=\"https:\/\/home.hirosaki-u.ac.jp\/mizutalab\/wp-content\/uploads\/sites\/95\/\/Screenshot-from-2023-08-14-10-16-01-300x186.png 300w, https:\/\/home.hirosaki-u.ac.jp\/mizutalab\/wp-content\/uploads\/sites\/95\/\/Screenshot-from-2023-08-14-10-16-01-644x398.png 644w, https:\/\/home.hirosaki-u.ac.jp\/mizutalab\/wp-content\/uploads\/sites\/95\/\/Screenshot-from-2023-08-14-10-16-01-768x475.png 768w, https:\/\/home.hirosaki-u.ac.jp\/mizutalab\/wp-content\/uploads\/sites\/95\/\/Screenshot-from-2023-08-14-10-16-01-2x1.png 2w, https:\/\/home.hirosaki-u.ac.jp\/mizutalab\/wp-content\/uploads\/sites\/95\/\/Screenshot-from-2023-08-14-10-16-01.png 1528w\" sizes=\"auto, (max-width: 377px) 100vw, 377px\" \/><\/p>\n<p>\u5de6\u56f3\u306e\u3088\u3046\u306b\u3001\u30a2\u30df\u30ce\u9178A\u3068\u30a2\u30df\u30ce\u9178C\u306b\u3001(1, 1)\u3068(-1, 1)\u306e\u30d9\u30af\u30c8\u30eb\u3092\u305d\u308c\u305e\u308c\u5272\u308a\u5f53\u3066\u307e\u3059\u3002\u3053\u306e\u30d9\u30af\u30c8\u30eb\u3092\u7528\u3044\u3066\u30a2\u30df\u30ce\u9178\u914d\u5217ACC\u3092\u30b0\u30e9\u30d5\u8868\u793a\u3059\u308b\u3068\u53f3\u56f3\u306e\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002\u539f\u70b9\u3092\u8996\u70b9\u3068\u3057\u3066\u3001\u30a2\u30df\u30ce\u9178\u914d\u5217\u306e\u30a2\u30df\u30ce\u9178\u3092\u5148\u982d\u304b\u3089\u9806\u756a\u306b\u8db3\u3057\u5408\u308f\u305b\u3066\u30d7\u30ed\u30c3\u30c8\u3057\u3001\u305d\u306e\u524d\u5f8c\u306e\u70b9\u3092\u7dda\u3067\u7d50\u3076\u3053\u3068\u3067\u30b0\u30e9\u30d5\u8868\u793a\u3092\u884c\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2 id=\"classification1\" style=\"border-bottom: 3px solid #013365;color: #013365\">\u751f\u7269\u7a2e\u5206\u985e\uff08\u30a2\u30df\u30ce\u9178\u914d\u5217\uff09<\/h2>\n<p>\u751f\u7269\u306f\u5171\u901a\u306e\u7956\u5148\u304b\u3089\u6d3e\u751f\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u7956\u5148\u304c\u6301\u3063\u3066\u3044\u305f\u907a\u4f1d\u5b50\u304c\u5f8c\u4ee3\u306b\u53d7\u3051\u7d99\u304c\u308c\u308b\u3053\u3068\u3067\u3001\u8fd1\u7e01\u7a2e\u540c\u58eb\u304c\u4f3c\u305f\u907a\u4f1d\u5b50\u3092\u5171\u6709\u3059\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u300e\u8fd1\u7e01\u7a2e\u540c\u58eb\u306f\u4f3c\u3066\u3044\u308b\u907a\u4f1d\u5b50\u3092\u6301\u3064\u300f\u3068\u3044\u3046\u6027\u8cea\u3092\u7528\u3044\u3066\u3001\u751f\u7269\u7a2e\u306b\u5206\u985e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u907a\u4f1d\u5b50\u3084\u914d\u5217\u306e\u6587\u5b57\u5217\u306f\u4e00\u822c\u7684\u306b\u9577\u304f\u3001\u76f4\u63a5\u6bd4\u8f03\u3057\u3066\u3082\u76f4\u89b3\u7684\u306b\u7406\u89e3\u3059\u308b\u3053\u3068\u306f\u96e3\u3057\u3044\u3067\u3059\u304c\u3001\u30b0\u30e9\u30d5\u8868\u793a\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u76f4\u611f\u7684\u306b\u7406\u89e3\u3057\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>20\u7a2e\u306e\u30a2\u30df\u30ce\u9178\u306b\u3001\u758e\u6c34\u6027\u5ea6\u3092\u8003\u616e\u3057\u305f\u30d9\u30af\u30c8\u30eb\u3092\u305d\u308c\u305e\u308c\u5272\u308a\u5f53\u3066\u307e\u3059\u3002\u5272\u308a\u5f53\u3066\u305f\u30d9\u30af\u30c8\u30eb\u306f\u4e0b\u56f3\u306e\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-60 aligncenter\" src=\"http:\/\/home.hirosaki-u.ac.jp\/mizutalab\/wp-content\/uploads\/sites\/95\/IMG_2749-300x300.jpg\" alt=\"\" width=\"215\" height=\"215\" srcset=\"https:\/\/home.hirosaki-u.ac.jp\/mizutalab\/wp-content\/uploads\/sites\/95\/\/IMG_2749-300x300.jpg 300w, https:\/\/home.hirosaki-u.ac.jp\/mizutalab\/wp-content\/uploads\/sites\/95\/\/IMG_2749-644x644.jpg 644w, https:\/\/home.hirosaki-u.ac.jp\/mizutalab\/wp-content\/uploads\/sites\/95\/\/IMG_2749-150x150.jpg 150w, https:\/\/home.hirosaki-u.ac.jp\/mizutalab\/wp-content\/uploads\/sites\/95\/\/IMG_2749-768x768.jpg 768w, https:\/\/home.hirosaki-u.ac.jp\/mizutalab\/wp-content\/uploads\/sites\/95\/\/IMG_2749-1x1.jpg 1w, https:\/\/home.hirosaki-u.ac.jp\/mizutalab\/wp-content\/uploads\/sites\/95\/\/IMG_2749.jpg 814w\" sizes=\"auto, (max-width: 215px) 100vw, 215px\" \/><\/p>\n<p>\u3053\u306e\u30d9\u30af\u30c8\u30eb\u3068\u30a2\u30df\u30ce\u9178\u914d\u5217\uff08\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2ND5\uff09\u3092\u7528\u3044\u3066\u4f5c\u6210\u3057\u305f\u30b0\u30e9\u30d5\u8868\u793a\u753b\u50cf\u306f\u4e0b\u56f3\u306e\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<div style=\"text-align: center\">\n<div>\n<figure><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-99 aligncenter\" src=\"http:\/\/home.hirosaki-u.ac.jp\/mizutalab\/wp-content\/uploads\/sites\/95\/tsuchiyama_graph-300x93.png\" alt=\"\" width=\"713\" height=\"221\" srcset=\"https:\/\/home.hirosaki-u.ac.jp\/mizutalab\/wp-content\/uploads\/sites\/95\/\/tsuchiyama_graph-300x93.png 300w, https:\/\/home.hirosaki-u.ac.jp\/mizutalab\/wp-content\/uploads\/sites\/95\/\/tsuchiyama_graph-644x199.png 644w, https:\/\/home.hirosaki-u.ac.jp\/mizutalab\/wp-content\/uploads\/sites\/95\/\/tsuchiyama_graph-768x238.png 768w, https:\/\/home.hirosaki-u.ac.jp\/mizutalab\/wp-content\/uploads\/sites\/95\/\/tsuchiyama_graph-3x1.png 3w, https:\/\/home.hirosaki-u.ac.jp\/mizutalab\/wp-content\/uploads\/sites\/95\/\/tsuchiyama_graph.png 905w\" sizes=\"auto, (max-width: 713px) 100vw, 713px\" \/><\/figure>\n<\/div>\n<\/div>\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u8fd1\u7e01\u7a2e\u540c\u58eb\u306e\u30b0\u30e9\u30d5\u306e\u6982\u5f62\u304c\u4f3c\u3066\u3044\u308b\u3053\u3068\u304c\u76f4\u89b3\u7684\u306b\u308f\u304b\u308a\u307e\u3059\u3002\u3053\u306e\u30b0\u30e9\u30d5\u3092\u7528\u3044\u3066\u3001\u751f\u7269\u7a2e\u306e\u5206\u985e\u3092\u884c\u3044\u307e\u3059\u3002<\/p>\n<h2 id=\"classification2\" style=\"color: #013365;border-bottom: 3px solid #013365\">\u30bf\u30f3\u30d1\u30af\u8cea\u30d5\u30a1\u30df\u30ea\u30fc\u5206\u985e\uff08\u30a2\u30df\u30ce\u9178\u914d\u5217\uff09<\/h2>\n<p>\u30bf\u30f3\u30d1\u30af\u8cea\u3082\u751f\u7269\u3068\u540c\u69d8\u306b\u9032\u5316\u3057\u3066\u304a\u308a\u3001\u5171\u901a\u306e\u7956\u5148\u3092\u6301\u3064\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u985e\u4f3c\u3057\u305f\u30a2\u30df\u30ce\u9178\u914d\u5217\u3092\u6301\u3063\u3066\u3044\u308b\u305f\u3081\u3001\u305d\u306e\u69cb\u9020\u3084\u6027\u8cea\u304c\u4f3c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u5171\u901a\u306e\u7956\u5148\u3092\u6301\u3064\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30b0\u30eb\u30fc\u30d7\u3092<a href=\"https:\/\/www.ebi.ac.uk\/training\/online\/courses\/protein-classification-intro-ebi-resources\/protein-classification\/what-are-protein-families\/\"><strong style=\"color: #013365\">\u30d5\u30a1\u30df\u30ea\u30fc<\/strong><\/a>\u3068\u3044\u3044\u307e\u3059\u3002\u672a\u77e5\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u5206\u985e\u3059\u308b\u3053\u3068\u3067\u3001\u305d\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u69cb\u9020\u3084\u6027\u8cea\u306a\u3069\u3092\u4e88\u6e2c\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<a href=\"https:\/\/www.cs.kent.ac.uk\/projects\/biasprofs\/\"><strong style=\"color: #013365\">BIASPROFS<\/strong><\/a>\u304c\u63d0\u4f9b\u3057\u3066\u308bGPCR\u30c7\u30fc\u30bf\u30bb\u30c3\u30c8\u3092\u7528\u3044\u3066\u3044\u307e\u3059\u3002GPCR\u3068\u306f\u3001G\u30bf\u30f3\u30d1\u30af\u8cea\u5171\u5f79\u53d7\u5bb9\u4f53\u3068\u3088\u3070\u308c\u5e02\u8ca9\u306e\u7d0450%\u306f\u3001GPCR\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u3057\u3066\u3044\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002GPCR\u30c7\u30fc\u30bf\u30bb\u30c3\u30c8\u306e\u6982\u8981\u3092\u4e0b\u8868\u306b\u793a\u3057\u307e\u3059\u3002<\/p>\n<table style=\"border-collapse: collapse;width: 100%;height: 144px\">\n<tbody>\n<tr style=\"height: 23px\">\n<td style=\"width: 10.5446%;height: 23px;text-align: left\">\u30af\u30e9\u30b9<\/td>\n<td style=\"width: 35.5736%;height: 23px;text-align: right\">\u8aac\u660e<\/td>\n<td style=\"width: 15.9907%;height: 23px;text-align: right\">\u30c7\u30fc\u30bf\u6570<\/td>\n<\/tr>\n<tr style=\"height: 23px\">\n<td style=\"width: 10.5446%;height: 23px;text-align: left\">A<\/td>\n<td style=\"width: 35.5736%;height: 23px;text-align: right\">\u30ed\u30c9\u30d7\u30b7\u30f3\u69d8\u53d7\u5bb9\u4f53<\/td>\n<td style=\"width: 15.9907%;height: 23px;text-align: right\">5392<\/td>\n<\/tr>\n<tr style=\"height: 23px\">\n<td style=\"width: 10.5446%;height: 23px\">B<\/td>\n<td style=\"width: 35.5736%;height: 23px;text-align: right\">\u30bb\u30af\u30ec\u30c1\u30f3\u69d8\u53d7\u5bb9\u4f53<\/td>\n<td style=\"width: 15.9907%;height: 23px;text-align: right\">463<\/td>\n<\/tr>\n<tr style=\"height: 23px\">\n<td style=\"width: 10.5446%;height: 23px;text-align: left\">C<\/td>\n<td style=\"width: 35.5736%;height: 23px;text-align: right\">\u4ee3\u8b1d\u578b\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u53d7\u5bb9\u4f53<\/td>\n<td style=\"width: 15.9907%;height: 23px;text-align: right\">2052<\/td>\n<\/tr>\n<tr style=\"height: 23px\">\n<td style=\"width: 10.5446%;height: 25px;text-align: left\">D<\/td>\n<td style=\"width: 35.5736%;height: 25px;text-align: right\">\u30d5\u30a7\u30ed\u30e2\u30f3\u53d7\u5bb9\u4f53<\/td>\n<td style=\"width: 15.9907%;height: 25px;text-align: right\">13<\/td>\n<\/tr>\n<tr style=\"height: 23px\">\n<td style=\"width: 10.5446%;height: 27px;text-align: left\">E<\/td>\n<td style=\"width: 35.5736%;height: 27px;text-align: right\">cAMP\u53d7\u5bb9\u4f53<\/td>\n<td style=\"width: 15.9907%;height: 27px;text-align: right\">19<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>20\u7a2e\u985e\u306e\u30a2\u30df\u30ce\u9178\u306b\u3001\u758e\u6c34\u6027\u5ea6\u3084\u5927\u304d\u3055\u306a\u3069\u306e\u7269\u7406\u7684\u7279\u6027\u3092\u8003\u616e\u3057\u305f\u30d9\u30af\u30c8\u30eb\u3092\u305d\u308c\u305e\u308c\u5272\u308a\u5f53\u3066\u307e\u3059\u3002\uff08\u4e0b\u56f3\uff09<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-120 aligncenter\" src=\"http:\/\/home.hirosaki-u.ac.jp\/mizutalab\/wp-content\/uploads\/sites\/95\/Screenshot-from-2023-08-14-10-14-51-300x177.png\" alt=\"\" width=\"390\" height=\"230\" srcset=\"https:\/\/home.hirosaki-u.ac.jp\/mizutalab\/wp-content\/uploads\/sites\/95\/\/Screenshot-from-2023-08-14-10-14-51-300x177.png 300w, https:\/\/home.hirosaki-u.ac.jp\/mizutalab\/wp-content\/uploads\/sites\/95\/\/Screenshot-from-2023-08-14-10-14-51-644x380.png 644w, https:\/\/home.hirosaki-u.ac.jp\/mizutalab\/wp-content\/uploads\/sites\/95\/\/Screenshot-from-2023-08-14-10-14-51-768x453.png 768w, https:\/\/home.hirosaki-u.ac.jp\/mizutalab\/wp-content\/uploads\/sites\/95\/\/Screenshot-from-2023-08-14-10-14-51-2x1.png 2w, https:\/\/home.hirosaki-u.ac.jp\/mizutalab\/wp-content\/uploads\/sites\/95\/\/Screenshot-from-2023-08-14-10-14-51.png 775w\" sizes=\"auto, (max-width: 390px) 100vw, 390px\" \/><\/p>\n<p>\u3053\u306e\u30d9\u30af\u30c8\u30eb\u3092\u7528\u3044\u3066\u4f5c\u6210\u3057\u305f\u30b0\u30e9\u30d5\u8868\u793a\u753b\u50cf\u3092\u4ee5\u4e0b\u306b\u793a\u3057\u307e\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-129 aligncenter\" 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